An example is the SmartDose electronic
4 Key Design Considerations
wearable injector system, which incorpo-
rates a polymer-based drug container and is
designed to enhance the experience of pa-
tients required to self-inject a larger volume
biologic drug in the home environment.
With home-based administration, there
can be an even greater challenge to staying
adherent. New technology helps to boost
motivation by incorporating game-like
technology that enables short-term rewards
for patients, enhancing the immediate value
of sticking with chronic therapies. In 2014,
West Pharmaceutical Services (www.west-
pharma.com) collaborated with HealthPrize
Technologies LLC ( www.healthprize.com)
— a leader in digital solutions for patient
engagement and medication adherence — to
tie rewards, education, and a gamification
platform directly to its injectable drug deliv-
ery systems to form a compelling end-to-
end connected health solution.
West is currently collaborating with
HealthPrize to enable connectivity between
a variety of injection systems and their
adherence programs to help improve adher-
ence and simplify the data capture process.
No matter what type of delivery system is
selected for a particular drug product, there
are several elements that must be carefully
considered when designing a drug delivery
In order to design a delivery system that
meets compliance requirements and the
needs of both the drug and the user, the
manufacturer must consider the interface
between the drug, container, delivery device,
and patient. It is also critical to “start with
the end in mind” and consider the method,
location, and person involved in the preparation and administration of the medicine.
1. Primary Container Format — The
selection of a drug’s primary container is an
important consideration for drug efficacy
and stability. Vials may be necessary for
initial use, but a syringe or cartridge system
may provide a desirable solution for the
patient when the system reaches the market.
Custom systems may also help to differentiate the product and should be considered
early in the development process.
2. Drug/Container Compatibility — Going
hand-in-hand with selecting the type of primary container is making sure the container
material can be safely and effectively paired
with the drug product. Is the elastomeric
material compatible with the drug? What
are the levels of extractables and leachables?
Will a barrier film or coating be required for
The West SmartDose electronic wearable
injector, designed for patient convenience,
uses a Daikyo Crystal Zenith cartridge and
can deliver a dose of up to 3.5mL, which
may allow for viscous biologics to be
administered over longer periods of time.
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KNF Neuberger, Inc.
Compact KNF Boxer-type diaphragm liquid pumps feature two pump
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