Motion made easy.
System Solutions from one single source
the most common method for quantifying
the number of stem cells or progenitors in
a given sample, is highly variable. Manual
counts of the same sample frequently differ
by 100% between observers and within the
same observer at different times. Furthermore, beyond just a number of colonies,
manual counts fail to provide quantitative
data on the features of each colony that
was counted. Nor do such counts create a
durable record of the status of each colony at
the time of assay.
Despite the enormous progress and
promise in the field of cell therapy development, unresolved challenges continue to
plague the community exploring cell-based
diagnostics. Dr. George Muschler of the
Cleveland Clinic, the Cell X innovator, characterizes these unresolved issues, “A critical
gap in current stem cell and progenitor cell
biology that limits translation into effective
therapies is our current inability to define
and measure critical quality attributes in the
stem cell and progenitor populations in our
labs today. These attributes must be defined
based on quantitative and standardized metrics. With this information, we can then act,
using appropriate tools, to rapidly identify
and isolate desired cells or clones, or to delete undesired cells/clones from our clinical
therapies and critical research studies.”
Automated Cell Handling
Cells are tiny, living, breathing things; as such,
they must be handled with precision and care.
Automated handling equipment in particular
needs a heightened level of dexterity and control. When looking at typical therapy processes, there are effectively two major processes.
1. Scanning and identification — Using
optics, in conjunction with motion systems
and control algorithms, to find cells or clus-
ters of cells of interest and identify their
location in 3D space.
2. Cell selection process — Utilizing in-
teractive surgical tools to selectively biopsy
cells of interest, remove undesired cells, or
transplant desired cells into a site where
they can be further expanded, processed,
Parker Hannifin ( www.parkermotion.
com) has designed several different platform products for manufacturability, modularity, and most importantly, performance.
The scanning and identification process
directly aligns with its experience in digital
pathology, enabling high precision, on-the-fly capture of high resolution images of cell
An mSR Series positioner from Parker positions cells for imaging and manipulation.